Scientists finetune hitting earth5/17/2023 ![]() ![]() “It looks like shutting down ETAA1 will attack cancer cells while leaving healthy cells alone. She agrees that the discovery can lead to improved cancer treatments in the future. We’ve tried lots of ways to slow down ATR, but this discovery can create a better way to attack cancer,” says Hansen. “Mailand and his group have discovered what I would describe as a “missing link” in identifying the function of ETAA1. She was not involved in the new research but has read the study. “This is absolutely important and exciting work,” says Lise Lotte Hansen, a lecturer at the Department of Biomedicine at Aarhus University, Denmark. “That tells me that ETAA1 plays an important role in the cancer cells’ defence against replication stress,” he says. Mailand is certain that ETAA1 could be an important factor in cancer cells’ stress relief.Īnalysis show that some cancer cells some have very little ETAA1, while other have a lot. Read More: Vitamin C supplements increase effectiveness of cancer treatmentĮTAA1 plays an important role in cancer cell defence Shutting off individual ETAA1 or TopB1 can perhaps be a more gentle for patient,” says Mailand. “It can be advantageous as it’s not merely an effective way to halt ATR’s function. Today, doctors can completely switch off ATR, but the new discovery can fine-tune the way in which doctors attack cancer by closing off specific parts of ATR. Slowing down ATR could help in the fight against cancer. ![]() “Until now we thought that it was a certain protein that initiated ATR, but we’ve shown that the ETAA1 protein also activates the ATR protein’s fight against replication stress,” says Mailand. It’s here that the new discovery can play an important role. Read More: Recycling approved drugs for cancer treatment Unfortunately, this approach also targets healthy cells. New treatments, currently being tested, use this knowledge to inhibit ATR and prevent cancers from growing too quickly. “You could say that cancer cells high jack the body’s ability to repair itself,” says Mailand. This means there’s a high chance of mistakes,” says Mailand.Īnd cancer cells make a lot of mistakes during the replication process so they are very dependent on the ATR-protein to ease the process, he says. “Cancer cells grow very quickly, and some grow too quickly for their own good. Read More: Scientists: we will never find a cure for cancerĬancer unravels the body’s ability to repair cellsĭiseases like cancer depend on the body’s ability to fight replication stress. Until now, we thought that ATR could only be activated by the TopBP1 protein, but we’ve now discovered that another protein can release ATR,” says Mailand. “The ATR proteins are the cells’ organiser in the fight against replication stress. Replication stress activates a protein called ATR to ease the stress and help the cell replication and division process continue as normal. ![]() This can trigger a process known as DNA replication stress, which increases the risk of faulty sequences in the copied DNA. ![]()
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